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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WWOX All Species: 25.45
Human Site: T349 Identified Species: 43.08
UniProt: Q9NZC7 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NZC7 NP_057457.1 414 46677 T349 F T L A R P F T K S M Q Q G A
Chimpanzee Pan troglodytes XP_001144696 363 41022 C299 A Y N R S K L C N I L F S N E
Rhesus Macaque Macaca mulatta XP_001105944 398 45056 S334 M Y S N I H R S W W V Y T L L
Dog Lupus familis XP_852623 383 43043 N319 S P R G V T S N A V H P G N M
Cat Felis silvestris
Mouse Mus musculus Q91WL8 414 46494 T349 F T L A R P F T K S M Q Q G A
Rat Rattus norvegicus NP_001099658 356 40173 A292 S D Y W A M L A Y N R S K L C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505354 146 16628 R81 F I D H I N K R T T Y L D P R
Chicken Gallus gallus Q5F389 414 46711 T349 F T L A R P F T K S M Q Q G A
Frog Xenopus laevis NP_001088080 143 16305 L79 Q I Y F V D H L N K R T T Y L
Zebra Danio Brachydanio rerio Q803A8 412 46303 T346 F S L A R P F T K S M Q Q G A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLU5 409 46492 T344 F A I V R P F T K S L Q Q A A
Honey Bee Apis mellifera XP_395282 414 46992 T342 F M L V R P F T K S L Q Q A A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789399 410 45991 T345 F L M V R P F T K S A T Q G A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42536 405 43844 Y337 L F P P F Q K Y I T K G Y V S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.5 84.7 82.8 N.A. 93.7 81.1 N.A. 26 83 29.2 71.9 N.A. 48.3 51.2 N.A. 56.2
Protein Similarity: 100 86.2 88.4 87.4 N.A. 96.1 83.8 N.A. 29.4 93 33.3 84.3 N.A. 65.2 66.6 N.A. 73.4
P-Site Identity: 100 0 0 0 N.A. 100 0 N.A. 6.6 100 0 93.3 N.A. 66.6 73.3 N.A. 66.6
P-Site Similarity: 100 6.6 13.3 0 N.A. 100 13.3 N.A. 13.3 100 0 100 N.A. 80 80 N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. 28.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 44.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 0 29 8 0 0 8 8 0 8 0 0 15 50 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % C
% Asp: 0 8 8 0 0 8 0 0 0 0 0 0 8 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % E
% Phe: 58 8 0 8 8 0 50 0 0 0 0 8 0 0 0 % F
% Gly: 0 0 0 8 0 0 0 0 0 0 0 8 8 36 0 % G
% His: 0 0 0 8 0 8 8 0 0 0 8 0 0 0 0 % H
% Ile: 0 15 8 0 15 0 0 0 8 8 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 8 15 0 50 8 8 0 8 0 0 % K
% Leu: 8 8 36 0 0 0 15 8 0 0 22 8 0 15 15 % L
% Met: 8 8 8 0 0 8 0 0 0 0 29 0 0 0 8 % M
% Asn: 0 0 8 8 0 8 0 8 15 8 0 0 0 15 0 % N
% Pro: 0 8 8 8 0 50 0 0 0 0 0 8 0 8 0 % P
% Gln: 8 0 0 0 0 8 0 0 0 0 0 43 50 0 0 % Q
% Arg: 0 0 8 8 50 0 8 8 0 0 15 0 0 0 8 % R
% Ser: 15 8 8 0 8 0 8 8 0 50 0 8 8 0 8 % S
% Thr: 0 22 0 0 0 8 0 50 8 15 0 15 15 0 0 % T
% Val: 0 0 0 22 15 0 0 0 0 8 8 0 0 8 0 % V
% Trp: 0 0 0 8 0 0 0 0 8 8 0 0 0 0 0 % W
% Tyr: 0 15 15 0 0 0 0 8 8 0 8 8 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _